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Superior visible light antimicrobial performance of facet engineered cobalt doped TiO₂ mesocrystals in pathogenic bacterium and fungi.

ABSTRACT: Pristine and Co-doped TiO₂ mesocrystals have been synthesized via a simple sol-gel method and their antimicrobial activity has been investigated. The antimicrobial performance was evaluated in terms of zone of inhibition, minimum inhibitory concentration (MIC), antibiofilm activity, and effect of UV illumination in liquid media. The Co-doped TiO₂ mesocrystals showed very promising MIC of 0.390 ?g/mL and 0.781 ?g/mL for P. mirabilis and P. mirabilis, respectively. Additionally, the material showed an MIC of 12.5 ?g/mL against C. albicans, suggesting its use as antifungal agent. Upon the addition of 10.0 µg/mL of Co-doped TiO₂ mesocrystals, the biofilm inhibition% reaches 84.43% for P. aeruginosa, 78.58% for P. mirabilis, and 77.81% for S. typhi, which can be ascribed to the created active oxygen species that decompose the tested microbial cells upon illumination. Thus the fabricated Co-doped TiO₂ mesocrystals exhibit sufficient antimicrobial features under visible light, qualifying them for use as antimicrobial agents against pathogenic bacteria and fungi and subsequently inhibit their hazardous effects.

SUBMITTER: El-Shazly AN

PROVIDER: S-EPMC7946932 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Superior visible light antimicrobial performance of facet engineered cobalt doped TiO2 mesocrystals in pathogenic bacterium and fungi.

El-Shazly Ayat N AN El-Sayyad Gharieb S GS Hegazy Aiat H AH Hamza Mahmoud A MA Fathy Rasha M RM El Shenawy E T ET Allam Nageh K NK

Scientific reports 20210310 1

Pristine and Co-doped TiO2 mesocrystals have been synthesized via a simple sol-gel method and their antimicrobial activity has been investigated. The antimicrobial performance was evaluated in terms of zone of inhibition, minimum inhibitory concentration (MIC), antibiofilm activity, and effect of UV illumination in liquid media. The Co-doped TiO2 mesocrystals showed very promising MIC of 0.390 μg/mL and 0.781 μg/mL for P. mirabilis and P. mirabilis, respectively. Additional ...[more]

PMID: 33692424

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Project description:The growing threat of emerging waterborne contaminants is a global concern, fuelled in part by the ineffectiveness of current remediation strategies. One of the most prominent remediation strategies is catalytic photodegradation, particularly with TiO2 nanoparticles (NPs), but its full utilization is hampered by using only UV radiation, which is scarce in sunlight. To fully benefit from the sunlight abundance, several efforts are focused on the tailoring of TiO2 to make it more active in visible (Vis) light. However, this target is yet to be met, sought for new developments. In a recent research paper entitled "Visible light-driven photodegradation of triclosan and antimicrobial activity against Legionella pneumophila with cobalt and nitrogen co-doped TiO2 anatase nanoparticles" [ 1 ], we investigated the co-doping potential of cobalt and nitrogen in TiO2 NPs for water decontamination, focusing on its application for the degradation of triclosan (TCS) under Vis LED light irradiation. Herein, the synthesis methodology for the preparation of doped TiO2 with nitrogen is described in detail, along with complementary data on the characterisation of all previously synthesised photocatalysts in the form of specific surface area determination (B.E.T. method) based on the obtained physisorption isotherms, X-ray photoelectron spectroscopy (XPS), and the automatic determination of bandgap energy through the diffuse reflectance spectra (DRS) analysis by using the GapExtractor© software. This dataset article also includes optimised photocatalytic reaction conditions, specifically conducted under monochromatic LED light irradiation. The employed LED irradiation conditions can support photocatalytic research in the field, since LED systems are costless and have a long-life span compared to most conventional UV-Vis systems. In addition, raw UV-Vis spectra and high-performance liquid chromatography (HPLC) chromatograms for monitoring the TCS degradation reaction are also included, as are powder X-ray diffractograms (XRD) of recycled doped-TiO2 photocatalysts, confirming the renewable efficiency of the synthesised photocatalysts to pursue green chemistry principles.

Dataset Information

Superior visible light antimicrobial performance of facet engineered cobalt doped TiO₂ mesocrystals in pathogenic bacterium and fungi.

Publications

Superior visible light antimicrobial performance of facet engineered cobalt doped TiO<sub>2</sub> mesocrystals in pathogenic bacterium and fungi.

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