Ontology highlight
ABSTRACT:
SUBMITTER: Morales P
PROVIDER: S-EPMC7949482 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Morales Paula P Lago-Fernandez Ana A Hurst Dow P DP Sotudeh Noori N Brailoiu Eugen E Reggio Patricia H PH Abood Mary E ME Jagerovic Nadine N
Journal of medicinal chemistry 20200923 23
GPR18 is a G-protein-coupled receptor that belongs to the orphan class A family. Even though it shares low sequence homology with the cannabinoid receptors CB<sub>1</sub>R and CB<sub>2</sub>R, a growing body of research suggests its relationship with the endocannabinoid system, not only because it is able to recognize cannabinoid ligands but also because of its expression and ability to heteromerize with CBRs. In this review, we aim to analyze the biological relevance, reported modulators, and s ...[more]