Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC7951984 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Wang Yanping Y Wu Xiaotong X Wang Zehua Z Chen Ting T Zhou Sicong S Chen Jiani J Pang Lan L Ye Xiqian X Shi Min M Huang Jianhua J Chen Xuexin X
PLoS pathogens 20210301 3
Parasites alter host energy homeostasis for their own development, but the mechanisms underlying this phenomenon remain largely unknown. Here, we show that Cotesia vestalis, an endoparasitic wasp of Plutella xylostella larvae, stimulates a reduction of host lipid levels. This process requires excess secretion of P. xylostella tachykinin (PxTK) peptides from enteroendocrine cells (EEs) in the midgut of the parasitized host larvae. We found that parasitization upregulates PxTK signaling to suppres ...[more]