Unknown

Dataset Information

0

Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling.


ABSTRACT: Parasites alter host energy homeostasis for their own development, but the mechanisms underlying this phenomenon remain largely unknown. Here, we show that Cotesia vestalis, an endoparasitic wasp of Plutella xylostella larvae, stimulates a reduction of host lipid levels. This process requires excess secretion of P. xylostella tachykinin (PxTK) peptides from enteroendocrine cells (EEs) in the midgut of the parasitized host larvae. We found that parasitization upregulates PxTK signaling to suppress lipogenesis in midgut enterocytes (ECs) in a non-cell-autonomous manner, and the reduced host lipid level benefits the development of wasp offspring and their subsequent parasitic ability. We further found that a C. vestalis bracovirus (CvBV) gene, CvBV 9-2, is responsible for PxTK induction, which in turn reduces the systemic lipid level of the host. Taken together, these findings illustrate a novel mechanism for parasite manipulation of host energy homeostasis by a symbiotic bracovirus gene to promote the development and increase the parasitic efficiency of an agriculturally important wasp species.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7951984 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling.

Wang Yanping Y   Wu Xiaotong X   Wang Zehua Z   Chen Ting T   Zhou Sicong S   Chen Jiani J   Pang Lan L   Ye Xiqian X   Shi Min M   Huang Jianhua J   Chen Xuexin X  

PLoS pathogens 20210301 3


Parasites alter host energy homeostasis for their own development, but the mechanisms underlying this phenomenon remain largely unknown. Here, we show that Cotesia vestalis, an endoparasitic wasp of Plutella xylostella larvae, stimulates a reduction of host lipid levels. This process requires excess secretion of P. xylostella tachykinin (PxTK) peptides from enteroendocrine cells (EEs) in the midgut of the parasitized host larvae. We found that parasitization upregulates PxTK signaling to suppres  ...[more]

Similar Datasets

| S-EPMC5960290 | biostudies-literature
| S-EPMC4325997 | biostudies-literature
| S-EPMC8448758 | biostudies-literature
| S-EPMC11819524 | biostudies-literature
| S-EPMC5310038 | biostudies-literature
| S-EPMC5339842 | biostudies-literature
| S-EPMC9095750 | biostudies-literature
| S-EPMC10826948 | biostudies-literature
| S-EPMC5290170 | biostudies-literature
| S-EPMC6491484 | biostudies-literature