Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC7952089 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Zhang Yaojun Y Xu Bin B Weiner Benjamin G BG Meir Yigal Y Wingreen Ned S NS
eLife 20210311
Cells possess a multiplicity of non-membrane-bound compartments, which form via liquid-liquid phase separation. These condensates assemble and dissolve as needed to enable central cellular functions. One important class of condensates is those composed of two associating polymer species that form one-to-one specific bonds. What are the physical principles that underlie phase separation in such systems? To address this question, we employed coarse-grained molecular dynamics simulations to examine ...[more]