Ontology highlight
ABSTRACT:
SUBMITTER: Longo JF
PROVIDER: S-EPMC7952412 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Longo Jody Fromm JF Brosius Stephanie N SN Znoyko Iya I Alers Victoria A VA Jenkins Dorea P DP Wilson Robert C RC Carroll Andrew J AJ Wolff Daynna J DJ Roth Kevin A KA Carroll Steven L SL
Scientific reports 20210311 1
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive Schwann cell-derived neoplasms that occur sporadically or in patients with neurofibromatosis type 1 (NF1). Preclinical research on sporadic MPNSTs has been limited as few cell lines exist. We generated and characterized a new sporadic MPNST cell line, 2XSB, which shares the molecular and genomic features of the parent tumor. These cells have a highly complex karyotype with extensive chromothripsis. 2XSB cells show robust invasive 3 ...[more]