Ontology highlight
ABSTRACT:
SUBMITTER: Jiang F
PROVIDER: S-EPMC7952549 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Jiang Fuman F Liu Weiqiang W Zhang Longmei L Guo Yulai Y Chen Min M Zeng Xiaojing X Wang Yang Y Li Yufan Y Xian JiaJia J Du BoLe B Xie Yuhuan Y Ouyang Shuming S Li Sheng S Yang Yinghong Y Zhang Chunsheng C Luo Fei F Sun Xiaofang X
Scientific reports 20210311 1
Noninvasive prenatal testing (NIPT) for single gene disorders remains challenging. One approach that allows for accurate detection of the slight increase of the maternally inherited allele is the relative haplotype dosage (RHDO) analysis, which requires the construction of parental haplotypes. Recently, the nanopore sequencing technologies have become available and may be an ideal tool for direct construction of haplotypes. Here, we explored the feasibility of combining nanopore sequencing with ...[more]