Ontology highlight
ABSTRACT:
SUBMITTER: Okuda A
PROVIDER: S-EPMC7952739 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Okuda Aya A Shimizu Masahiro M Morishima Ken K Inoue Rintaro R Sato Nobuhiro N Urade Reiko R Sugiyama Masaaki M
Scientific reports 20210311 1
Multi-domain proteins (MDPs) show a variety of domain conformations under physiological conditions, regulating their functions through such conformational changes. One of the typical MDPs, ER-60 which is a protein folding enzyme, has a U-shape with four domains and is thought to have different domain conformations in solution depending on the redox state at the active centres of the edge domains. In this work, an aggregation-free small-angle X-ray scattering revealed that the structures of oxidi ...[more]