Ontology highlight
ABSTRACT:
SUBMITTER: Zhang R
PROVIDER: S-EPMC7953826 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Zhang Ruihui R Lee Donghoon M DM Jimah John R JR Gerassimov Nathalie N Yang Changsong C Kim Sangjoon S Luvsanjav Delgermaa D Winkelman Jonathan J Mettlen Marcel M Abrams Michael E ME Kalia Raghav R Keene Peter P Pandey Pratima P Ravaux Benjamin B Kim Ji Hoon JH Ditlev Jonathon A JA Zhang Guofeng G Rosen Michael K MK Frost Adam A Alto Neal M NM Gardel Margaret M Schmid Sandra L SL Svitkina Tatyana M TM Hinshaw Jenny E JE Chen Elizabeth H EH
Nature cell biology 20200525 6
The dynamin GTPase is known to bundle actin filaments, but the underlying molecular mechanism and physiological relevance remain unclear. Our genetic analyses revealed a function of dynamin in propelling invasive membrane protrusions during myoblast fusion in vivo. Using biochemistry, total internal reflection fluorescence microscopy, electron microscopy and cryo-electron tomography, we show that dynamin bundles actin while forming a helical structure. At its full capacity, each dynamin helix ca ...[more]