Ontology highlight
ABSTRACT:
SUBMITTER: Hoffmann HH
PROVIDER: S-EPMC7954666 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Cell 20201209 1
Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host factors required for flavivirus infection, we performed full-genome loss of function CRISPR-Cas9 screens. Based on these results, we focused our efforts on characterizing the roles that TMEM41B and VMP1 play in the virus replication cycle. Our mechanistic studies on TMEM41B revealed that all members of the Flaviviridae ...[more]