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Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications.

ABSTRACT: Chromatin functions are influenced by the addition, removal, and recognition of histone post-translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone proteins can function as signaling molecules by mediating protein-protein interactions. Fueled by the identification of novel ubiquitin and UBL sites and the characterization of the writers, erasers, and readers, the breadth of chromatin functions associated with ubiquitin signaling is emerging. Here, we highlight recently appreciated roles for histone ubiquitination in DNA methylation control, PTM crosstalk, nucleosome structure, and phase separation. We also discuss the expanding diversity and functions associated with histone UBL modifications. We conclude with a look toward the future and pose key questions that will drive continued discovery at the interface of epigenetics and ubiquitin signaling.

SUBMITTER: Vaughan RM

PROVIDER: S-EPMC7954875 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications.

Vaughan Robert M RM Kupai Ariana A Rothbart Scott B SB

Trends in biochemical sciences 20201209 4

Chromatin functions are influenced by the addition, removal, and recognition of histone post-translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone proteins can function as signaling molecules by mediating protein-protein interactions. Fueled by the identification of novel ubiquitin and UBL sites and the characterization of the writers, erasers, and readers, the breadth of chromatin functions associated with ubiquitin signaling is emerging. Here, we highlight rece ...[more]

PMID: 33308996

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