Ontology highlight
ABSTRACT:
SUBMITTER: Gayoso A
PROVIDER: S-EPMC7954949 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Gayoso Adam A Steier Zoë Z Lopez Romain R Regier Jeffrey J Nazor Kristopher L KL Streets Aaron A Yosef Nir N
Nature methods 20210215 3
The paired measurement of RNA and surface proteins in single cells with cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) is a promising approach to connect transcriptional variation with cell phenotypes and functions. However, combining these paired views into a unified representation of cell state is made challenging by the unique technical characteristics of each measurement. Here we present Total Variational Inference (totalVI; https://scvi-tools.org ), a framework fo ...[more]