Ontology highlight
ABSTRACT:
SUBMITTER: Luo L
PROVIDER: S-EPMC7955895 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Luo Lan L Chen Yuhong Y Chen Xiao X Zheng Yongwei Y Zhou Vivian V Yu Mei M Burns Robert R Zhu Wen W Fu Guoping G Felix Juan C JC Hartley Christopher C Damnernsawad Alisa A Zhang Jing J Wen Renren R Drobyski Williams R WR Gao Chunji C Wang Demin D
Journal of immunology (Baltimore, Md. : 1950) 20201106 12
Acute graft-versus-host disease (aGVHD) is one major serious complication that is induced by alloreactive donor T cells recognizing host Ags and limits the success of allogeneic hematopoietic stem cell transplantation. In the current studies, we identified a critical role of Kras in regulating alloreactive T cell function during aGVHD. Kras deletion in donor T cells dramatically reduced aGVHD mortality and severity in an MHC-mismatched allogeneic hematopoietic stem cell transplantation mouse mod ...[more]