USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer.

ABSTRACT: Tumor cell dissemination in cancer patients is associated with a significant reduction in their survival and quality of life. The ubiquitination pathway plays a fundamental role in the maintenance of protein homeostasis both in normal and stressed conditions and its dysregulation has been associated with malignant transformation and invasive potential of tumor cells, thus highlighting its value as a potential therapeutic target. In order to identify novel molecular targets of tumor cell migration and invasion we performed a genetic screen with an shRNA library against ubiquitination pathway-related genes. To this end, we set up a protocol to specifically enrich positive migration regulator candidates. We identified the deubiquitinase USP19 and demonstrated that its silencing reduces the mi

SUBMITTER: Rossi FA 

PROVIDER: S-EPMC7956144 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature