Ontology highlight
ABSTRACT:
SUBMITTER: Chang-Graham AL
PROVIDER: S-EPMC7957961 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20201101 6519
Rotavirus causes severe diarrheal disease in children by broadly dysregulating intestinal homeostasis. However, the underlying mechanism(s) of rotavirus-induced dysregulation remains unclear. We found that rotavirus-infected cells produce paracrine signals that manifested as intercellular calcium waves (ICWs), observed in cell lines and human intestinal enteroids. Rotavirus ICWs were caused by the release of extracellular adenosine 5'-diphosphate (ADP) that activated P2Y1 purinergic receptors on ...[more]