Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC7958421 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Wu Jianxuan J Bao Chunjing C Reinhardt R Lee RL Abraham Soman N SN
Proceedings of the National Academy of Sciences of the United States of America 20210301 10
Given the high frequency of urinary tract infections (UTIs) and their recurrence, there is keen interest in developing effective UTI vaccines. Currently, most vaccine studies, including those in humans, involve parenteral vaccination aimed at evoking and sustaining elevated levels of systemic antibody directed at the uropathogens. In view of recent reports of aberrant Th2-biased bladder immune responses to infection, we hypothesized that immunizing mice intravesically with antigens from uropatho ...[more]