Ontology highlight
ABSTRACT:
SUBMITTER: Awasthi S
PROVIDER: S-EPMC7958587 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Awasthi Samir S Wagner Tyler T Venkatakrishnan A J AJ Puranik Arjun A Hurchik Matthew M Agarwal Vineet V Conrad Ian I Kirkup Christian C Arunachalam Raman R O'Horo John J Kremers Walter W Kashyap Rahul R Morice William W Halamka John J Williams Amy W AW Faubion William A WA Badley Andrew D AD Gores Gregory J GJ Soundararajan Venky V
Cell death discovery 20210315 1
Intensive care unit (ICU) admissions and mortality in severe COVID-19 patients are driven by "cytokine storms" and acute respiratory distress syndrome (ARDS). Interim clinical trial results suggest that the corticosteroid dexamethasone displays better 28-day survival in severe COVID-19 patients requiring ventilation or oxygen. In this study, 10 out of 16 patients (62.5%) that had an average plasma IL-6 value over 10 pg/mL post administration of corticosteroids also had worse outcomes (i.e., ICU ...[more]