Ontology highlight
ABSTRACT:
SUBMITTER: Sikora M
PROVIDER: S-EPMC7959525 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Sikora Mateusz M Ermel Utz H UH Seybold Anna A Kunz Michael M Calloni Giulia G Reitz Julian J Vabulas R Martin RM Hummer Gerhard G Frangakis Achilleas S AS
Proceedings of the National Academy of Sciences of the United States of America 20201016 44
Desmosomes are cell-cell junctions that link tissue cells experiencing intense mechanical stress. Although the structure of the desmosomal cadherins is known, the desmosome architecture-which is essential for mediating numerous functions-remains elusive. Here, we recorded cryo-electron tomograms (cryo-ET) in which individual cadherins can be discerned; they appear variable in shape, spacing, and tilt with respect to the membrane. The resulting sub-tomogram average reaches a resolution of ∼26 Å, ...[more]