Association of amyloid-β CSF/PET discordance and tau load 5 years later.

ABSTRACT:

Objective

To investigate the association between discordant β-amyloid (Aβ) PET and CSF biomarkers at baseline and the emergence of tau pathology 5 years later.

Methods

We included 730 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants without dementia (282 cognitively normal, 448 mild cognitive impairment) with baseline [¹⁸F]florbetapir PET and CSF Aβ₄₂ available. Aβ CSF/PET status was determined at baseline using established cutoffs. Longitudinal data were available for [¹⁸F]florbetapir (Aβ) PET (baseline to 4.3 ± 1.9 years), CSF (p)tau (baseline to 2.0 ± 0.1 years), cognition (baseline to 4.3 ± 2.0 years), and [¹⁸F]flortaucipir (tau) PET (measured 5.2 ± 1.2 years after baseline to 1.6 ± 0.7 years later). We used line

SUBMITTER: Reimand J 

PROVIDER: S-EPMC7963352 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature