Diffusion magnetic resonance imaging assessment of regional white matter maturation in preterm neonates.

ABSTRACT:

Purpose

Diffusion magnetic resonance imaging (dMRI) studies report altered white matter (WM) development in preterm infants. Neurite orientation dispersion and density imaging (NODDI) metrics provide more realistic estimations of neurite architecture in vivo compared with standard diffusion tensor imaging (DTI) metrics. This study investigated microstructural maturation of WM in preterm neonates scanned between 25 and 45 weeks postmenstrual age (PMA) with normal neurodevelopmental outcomes at 2 years using DTI and NODDI metrics.

Methods

Thirty-one neonates (n = 17 male) with median (range) gestational age (GA) 32⁺¹ weeks (24⁺²-36⁺⁴) underwent 3 T brain MRI at median (range) post menstrual age (PMA) 35⁺² weeks (25⁺³-43

SUBMITTER: Kimpton JA 

PROVIDER: S-EPMC7966229 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature