Evaluation of gene expression and protein structural modeling involved in persister cell formation in Salmonella Typhimurium.

ABSTRACT: Persisters are phenotypic variants of the bacterial population that survive against lethal doses of bactericidal antibiotics.These phenotypes are created in numerous bacterial species, including those of clinical significance, such as Salmonella Typhimurium. Since persister cells are associated with the failure of antibiotic treatment and infection recurrence, it is crucial to identify the mechanisms that influence the formation of these cells. The aim of this study is to investigate the persister cell formation and expression analysis as well as to predict the 3D structure of the genes involved in the production of persister cells. The presence of persisters in S. Typhimurium was determined by time dependent killing of different types of bactericidal antibiotics and expression of genes as

SUBMITTER: Narimisa N 

PROVIDER: S-EPMC7966607 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature