Ontology highlight
ABSTRACT:
SUBMITTER: Zhu W
PROVIDER: S-EPMC7969007 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Nucleic acids research 20210301 5
Cells and organisms have a wide range of mechanisms to defend against infection by viruses and other mobile genetic elements (MGE). Type III CRISPR systems detect foreign RNA and typically generate cyclic oligoadenylate (cOA) second messengers that bind to ancillary proteins with CARF (CRISPR associated Rossman fold) domains. This results in the activation of fused effector domains for antiviral defence. The best characterised CARF family effectors are the Csm6/Csx1 ribonucleases and DNA nickase ...[more]