LASCA: loop and significant contact annotation pipeline.
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ABSTRACT:
SUBMITTER: Luzhin AV
PROVIDER: S-EPMC7973524 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
LASCA: loop and significant contact annotation pipeline.
Luzhin Artem V AV Golov Arkadiy K AK Gavrilov Alexey A AA Velichko Artem K AK Ulianov Sergey V SV Razin Sergey V SV Kantidze Omar L OL
Scientific reports 20210318 1
Chromatin loops represent one of the major levels of hierarchical folding of the genome. Although the situation is evolving, current methods have various difficulties with the accurate mapping of loops even in mammalian Hi-C data, and most of them fail to identify chromatin loops in animal species with substantially different genome architecture. This paper presents the loop and significant contact annotation (LASCA) pipeline, which uses Weibull distribution-based modeling to effectively identif ...[more]
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