Dataset Information

Molecular characterization of high-risk human papillomavirus (HR-HPV) in women in Lome, Togo.

ABSTRACT:

Background

The causative agent of cervical cancer referred to as Human papillomavirus (HPV) remains a real public health problem. Many countries in West Africa, such as Togo have no data on the high-risk HPV (HR-HPV) infection and genotypes distribution. In order to fill the knowledge gap in the field in Togo, the main objective of this study was to determine the prevalence of pre-cancerous lesions of the cervix and HR-HPV genotypes among Togolese women.

Methods

Samples were collected from 240 women by introducing a swab in the cervix. Then, the screening of precancerous cervical lesions using the visual inspection with acetic acid and lugol (VIA / VIL) was conducted. The HR-HPV genotypes were characterised by real-time multiplex PCR.

Results

Out of 240 women recruited, 128 (53.3%) were infected by HR-HPV. The most common genotypes were HPV 56 (22.7%), followed by HPV 51 (20.3%), HPV 31 (19.5%), HPV 52 (18.8%) and HPV 35 (17.2%). The least common genotypes were HPV 33 (2.3%) and HPV 16 (2.3%). Among the women, 1.3% (3/240) were positive to VIA/VIL.

Conclusion

This study allowed HR-HPV genotypes to be characterised for the first time in Lomé, Togo. This will help in mapping the HR-HPV genotypes in West Africa.

SUBMITTER: Kuassi-Kpede AP

PROVIDER: S-EPMC7977574 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Molecular characterization of high-risk human papillomavirus (HR-HPV) in women in Lomé, Togo.

Kuassi-Kpede Akouélé P AP Dolou Essolakina E Zohoncon Théodora M TM Traore Ina Marie Angèle IMA Katawa Gnatoulma G Ouedraogo R Alice RA Traore Esther Mah EM Bado Prosper P Ouedraogo T Clarisse TC Djigma Florencia Wendkuuni FW Karou Simplice Damintoti SD Simpore Jacques J

BMC infectious diseases 20210319 1

<h4>Background</h4>The causative agent of cervical cancer referred to as Human papillomavirus (HPV) remains a real public health problem. Many countries in West Africa, such as Togo have no data on the high-risk HPV (HR-HPV) infection and genotypes distribution. In order to fill the knowledge gap in the field in Togo, the main objective of this study was to determine the prevalence of pre-cancerous lesions of the cervix and HR-HPV genotypes among Togolese women.<h4>Methods</h4>Samples were colle ...[more]

PMID: 33740909

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