Ontology highlight
ABSTRACT:
SUBMITTER: Dobramysl U
PROVIDER: S-EPMC7980258 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Dobramysl Ulrich U Jarsch Iris Katharina IK Inoue Yoshiko Y Shimo Hanae H Richier Benjamin B Gadsby Jonathan R JR Mason Julia J Szałapak Alicja A Ioannou Pantelis Savvas PS Correia Guilherme Pereira GP Walrant Astrid A Butler Richard R Hannezo Edouard E Simons Benjamin D BD Gallop Jennifer L JL
The Journal of cell biology 20210401 4
Assemblies of actin and its regulators underlie the dynamic morphology of all eukaryotic cells. To understand how actin regulatory proteins work together to generate actin-rich structures such as filopodia, we analyzed the localization of diverse actin regulators within filopodia in Drosophila embryos and in a complementary in vitro system of filopodia-like structures (FLSs). We found that the composition of the regulatory protein complex where actin is incorporated (the filopodial tip complex) ...[more]