Incipient resistance to an effective pesticide results from genetic adaptation and the canalization of gene expression.

ABSTRACT: The resistance of pest species to chemical controls has vast ecological, economic, and societal costs. In most cases, resistance is only detected after spreading throughout an entire population. Detecting resistance in its incipient stages, by comparison, provides time to implement preventative strategies. Incipient resistance can be detected by coupling standard toxicology assays with large-scale gene expression experiments. We apply this approach to a system where an invasive parasite, sea lamprey (Petromyzon marinus), has been treated with the highly effective pesticide 3-trifluoromethyl-4-nitrophenol (TFM) for 60 years. Toxicological experiments revealed that lamprey from treated populations did not have higher survival to TFM exposure than lamprey from untreated populations, de

SUBMITTER: Yin X 

PROVIDER: S-EPMC7980271 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature