Modeling programmable drug delivery in bioelectronics with electrochemical actuation.

ABSTRACT: Drug delivery systems featuring electrochemical actuation represent an emerging class of biomedical technology with programmable volume/flowrate capabilities for localized delivery. Recent work establishes applications in neuroscience experiments involving small animals in the context of pharmacological response. However, for programmable delivery, the available flowrate control and delivery time models fail to consider key variables of the drug delivery system--microfluidic resistance and membrane stiffness. Here we establish an analytical model that accounts for the missing variables and provides a scalable understanding of each variable influence in the physics of delivery process (i.e., maximum flowrate, delivery time). This analytical model accounts for the key parameters--initial env

SUBMITTER: Avila R 

PROVIDER: S-EPMC7980470 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature