Ontology highlight
ABSTRACT:
SUBMITTER: Flower TG
PROVIDER: S-EPMC7980513 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Flower Thomas G TG Hurley James H JH
Protein science : a publication of the Protein Society 20210304 4
The majority of crystal structures are determined by the method of molecular replacement (MR). The range of application of MR is limited mainly by the need for an accurate search model. In most cases, pre-existing experimentally determined structures are used as search models. In favorable cases, ab initio predicted structures have yielded search models adequate for MR. The ORF8 protein of SARS-CoV-2 represents a challenging case for MR using an ab initio prediction because ORF8 has an all β-she ...[more]