Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC7982428 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Zhang Jinghui J Fan Jiajun J Zeng Xian X Nie Mingming M Luan Jingyun J Wang Yichen Y Ju Dianwen D Yin Kai K
Acta pharmaceutica Sinica. B 20201029 3
The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance. The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflamma ...[more]