Categorisation of Pharmaceutical Adverse Events Using the Japanese Adverse Drug Event Report Database: Characteristic Adverse Drug Events of the Elderly Treated with Polypharmacy.

ABSTRACT:

Background

Pharmacokinetics and pharmacodynamics of drugs in elderly individuals differ from those in younger adults; thus, adverse drug events (ADEs) are common in older patients with polypharmacy because co-existing comorbidities elevate the risk of ADEs occurring. However, ADEs have not yet been characterised based on the elderly patients of Japanese origin and polypharmacy.

Objective

The 100 most commonly reported ADEs were grouped into four classes (Class 1-Class 4) based on elderly patients with polypharmacy.

Patients and methods

In this study, logistic regression analysis was performed using cases recorded in the Japanese Adverse Drug Event Report (JADER) database.

Results

ADEs in elderly patients treated with polypharmacy-in whom the risk of electrolyte

SUBMITTER: Negishi A 

PROVIDER: S-EPMC7984209 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature