Dataset Information

Dementia in Latin America: Paving the way toward a regional action plan.

ABSTRACT: Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

SUBMITTER: Parra MA

PROVIDER: S-EPMC7984223 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Dementia in Latin America: Paving the way toward a regional action plan.

Parra Mario Alfredo MA Baez Sandra S Sedeño Lucas L Gonzalez Campo Cecilia C Santamaría-García Hernando H Aprahamian Ivan I Bertolucci Paulo Hf PH Bustin Julian J Camargos Bicalho Maria Aparecida MA Cano-Gutierrez Carlos C Caramelli Paulo P Chaves Marcia L F MLF Cogram Patricia P Beber Bárbara Costa BC Court Felipe A FA de Souza Leonardo Cruz LC Custodio Nilton N Damian Andres A de la Cruz Myriam M Diehl Rodriguez Roberta R Brucki Sonia Maria Dozzi SMD Fajersztajn Lais L Farías Gonzalo A GA De Felice Fernanda G FG Ferrari Raffaele R de Oliveira Fabricio Ferreira FF Ferreira Sergio T ST Ferretti Ceres C Figueredo Balthazar Marcio Luiz ML Ferreira Frota Norberto Anizio NA Fuentes Patricio P García Adolfo M AM Garcia Patricia J PJ de Gobbi Porto Fábio Henrique FH Duque Peñailillo Lissette L Engler Henry Willy HW Maier Irene I Mata Ignacio F IF Gonzalez-Billault Christian C Lopez Oscar L OL Morelli Laura L Nitrini Ricardo R Quiroz Yakeel T YT Guerrero Barragan Alejandra A Huepe David D Pio Fabricio Joao FJ Suemoto Claudia Kimie CK Kochhann Renata R Kochen Silvia S Kumfor Fiona F Lanata Serggio S Miller Bruce B Mansur Leticia Lessa LL Hosogi Mirna Lie ML Lillo Patricia P Llibre Guerra Jorge J Lira David D Lopera Francisco F Comas Adelina A Avila-Funes José Alberto JA Sosa Ana Luisa AL Ramos Claudia C Resende Elisa de Paula França EPF Snyder Heather M HM Tarnanas Ioannis I Yokoyama Jenifer J Llibre Juan J Cardona Juan Felipe JF Possin Kate K Kosik Kenneth S KS Montesinos Rosa R Moguilner Sebastian S Solis Patricia Cristina Lourdes PCL Ferretti-Rebustini Renata Eloah de Lucena REL Ramirez Jeronimo Martin JM Matallana Diana D Mbakile-Mahlanza Lingani L Marques Ton Alyne Mendonça AM Tavares Ronnielly Melo RM Miotto Eliane C EC Muniz-Terrera Graciela G Muñoz-Nevárez Luis Arnoldo LA Orozco David D Okada de Oliveira Maira M Piguet Olivier O Pintado Caipa Maritza M Piña Escudero Stefanie Danielle SD Schilling Lucas Porcello LP Rodrigues Palmeira André Luiz AL Yassuda Mônica Sanches MS Santacruz-Escudero Jose Manuel JM Serafim Rodrigo Bernardo RB Smid Jerusa J Slachevsky Andrea A Serrano Cecilia C Soto-Añari Marcio M Takada Leonel Tadao LT Grinberg Lea Tenenholz LT Teixeira Antonio Lucio AL Barbosa Maira Tonidandel MT Trépel Dominic D Ibanez Agustin A

Alzheimer's & dementia : the journal of the Alzheimer's Association 20201120 2

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-ba ...[more]

PMID: 33634602

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Project description:The Global Horizon Scanning Project (GHSP) is an innovative initiative that aims to identify important global environmental quality research needs. Here we report 20 key research questions from Latin America (LA). Members of the Society of Environmental Toxicology and Chemistry (SETAC) LA and other scientists from LA were asked to submit research questions that would represent priority needs to address in the region. One hundred questions were received, then partitioned among categories, examined, and some rearranged during a workshop in Buenos Aires, Argentina. Twenty priority research questions were subsequently identified. These research questions included developing, improving, and harmonizing across LA countries methods for 1) identifying contaminants and degradation products in complex matrices (including biota); 2) advancing prediction of contaminant risks and effects in ecosystems, addressing lab-to-field extrapolation challenges, and understanding complexities of multiple stressors (including chemicals and climate change); and 3) improving management and regulatory tools toward achieving sustainable development. Whereas environmental contaminants frequently identified in these key questions were pesticides, pharmaceuticals, endocrine disruptors or modulators, plastics, and nanomaterials, commonly identified environmental challenges were related to agriculture, urban effluents, solid wastes, pulp and paper mills, and natural extraction activities. Several interesting research topics included assessing and preventing pollution impacts on conservation protected areas, integrating environment and health assessments, and developing strategies for identification, substitution, and design of less hazardous chemicals (e.g., green chemistry). Finally, a recurrent research need included developing an understanding of differential sensitivity of regional species and ecosystems to environmental contaminants and other stressors. Addressing these critical questions will support development of long-term strategic research efforts to advance more sustainable environmental quality and protect public health and the environment in LA. Integr Environ Assess Manag 2018;14:344-357. © 2018 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

Project description:Patients with bilateral vestibulopathy (BVP) present with unsteadiness during standing and walking, limiting their activities of daily life and, more importantly, resulting in an increased risk of falling. In BVP patients, falls are considered as one of the major complications, with patients having a 31-fold increased risk of falling compared to healthy subjects. Thus, highlighting objective measures that can easily and accurately assess the risk of falling in BVP patients is an important step in reducing the incidence of falls and the accompanying burdens. Therefore, this study investigated the interrelations between demographic characteristics, vestibular function, questionnaires on self-perceived handicap and balance confidence, clinical balance measures, gait variables, and fall status in 27 BVP patients. Based on the history of falls in the preceding 12 months, the patients were subdivided in a "faller" or "non-faller" group. Results on the different outcome measures were compared between the "faller" and "non-faller" subgroups using Pearson's chi-square test in the case of categorical data; for continuous data, Mann-Whitney U test was used. Performances on the clinical balance measures were comparable between fallers and non-fallers, indicating that, independent from fall status, the BVP patients present with an increased risk of falling. However, fallers tended to report a worse self-perceived handicap and confidence during performing activities of daily life. Spatiotemporal parameters of gait did not differ between fallers and non-fallers during walking at slow, preferred, or fast walking speed. These results may thus imply that, when aiming to distinguish fallers from non-fallers, the BVP patients' beliefs concerning their capabilities may be more important than the moderately or severely affected physical performance within a clinical setting. Outcome measures addressing the self-efficacy and fear of falling in BVP patients should therefore be incorporated in future research to investigate whether these are indeed able to distinguish fallers form non-fallers. Additionally, information regarding physical activity could provide valuable insights on the contextual information influencing behavior and falls in BVP.

Dataset Information

Dementia in Latin America: Paving the way toward a regional action plan.

Publications

Dementia in Latin America: Paving the way toward a regional action plan.

Similar Datasets

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