Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.

ABSTRACT: Association studies have linked microbiome alterations with many human diseases. However, they have not always reported consistent results, thereby necessitating cross-study comparisons. Here, a meta-analysis of eight geographically and technically diverse fecal shotgun metagenomic studies of colorectal cancer (CRC, n = 768), which was controlled for several confounders, identified a core set of 29 species significantly enriched in CRC metagenomes (false discovery rate (FDR) < 1 × 10^-5). CRC signatures derived from single studies maintained their accuracy in other studies. By training on multiple studies, we improved detection accuracy and disease specificity for CRC. Functional analysis of CRC metagenomes revealed enriched protein and mucin catabolism genes and depleted carbohy

SUBMITTER: Wirbel J 

PROVIDER: S-EPMC7984229 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature