Ontology highlight
ABSTRACT:
SUBMITTER: Hennemann LC
PROVIDER: S-EPMC7984618 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Hennemann Lisa C LC LaFayette Shantelle L SL Malet Julien K JK Bortolotti Perrine P Yang Tianxiao T McKay Geoffrey A GA Houle Daniel D Radzioch Danuta D Rousseau Simon S Nguyen Dao D
PLoS pathogens 20210310 3
Pseudomonas aeruginosa causes chronic airway infections, a major determinant of lung inflammation and damage in cystic fibrosis (CF). Loss-of-function lasR mutants commonly arise during chronic CF infections, are associated with accelerated lung function decline in CF patients and induce exaggerated neutrophilic inflammation in model systems. In this study, we investigated how lasR mutants modulate airway epithelial membrane bound ICAM-1 (mICAM-1), a surface adhesion molecule, and determined its ...[more]