Rapid Changes in Serum Testosterone in Men With Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin.

ABSTRACT:

Objective

To investigate the effect of metformin on testosterone levels in men with type 2 diabetes mellitus (T2DM).

Research design and methods

Seventy men with newly diagnosed drug-naive T2DM and HbA_1c >9.0% (75 mmol/mol) were treated with intensive insulin pump therapy for 5 days to achieve glucose normalization. They were randomized to control (continued on intensive insulin only) and metformin (plus metformin) groups (1:1) for 1 month. Testosterone was measured at baseline, randomization, and after 1-month treatment.

Results

Total, free, and bioavailable testosterone increased significantly within 5 days (all P < 0.001). After 1 month, compared with the control group, the metformin group had lower total (12.7 vs. 15.3 nmol/L), free (0.20 vs. 0.2

SUBMITTER: Hu Y 

PROVIDER: S-EPMC7985426 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature