Ontology highlight
ABSTRACT:
SUBMITTER: Harada S
PROVIDER: S-EPMC7986096 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Harada Seiko S Mabuchi Yo Y Kohyama Jun J Shimojo Daisuke D Suzuki Sadafumi S Kawamura Yoshimi Y Araki Daisuke D Suyama Takashi T Kajikawa Masunori M Akazawa Chihiro C Okano Hideyuki H Matsuzaki Yumi Y
Stem cells (Dayton, Ohio) 20201222 3
Human mesenchymal stem/stromal cells (hMSCs) have garnered enormous interest as a potential resource for cell-based therapies. However, the molecular mechanisms regulating senescence in hMSCs remain unclear. To elucidate these mechanisms, we performed gene expression profiling to compare clonal immature MSCs exhibiting multipotency with less potent MSCs. We found that the transcription factor Frizzled 5 (FZD5) is expressed specifically in immature hMSCs. The FZD5 cell surface antigen was also hi ...[more]