Lipid transfer proteins and instructive regulation of lipid kinase activities: Implications for inositol lipid signaling and disease.

ABSTRACT: Cellular membranes are critical platforms for intracellular signaling that involve complex interfaces between lipids and proteins, and a web of interactions between a multitude of lipid metabolic pathways. Membrane lipids impart structural and functional information in this regulatory circuit that encompass biophysical parameters such as membrane thickness and fluidity, as well as chaperoning the interactions of protein binding partners. Phosphatidylinositol and its phosphorylated derivatives, the phosphoinositides, play key roles in intracellular membrane signaling, and these involvements are translated into an impressively diverse set of biological outcomes. The phosphatidylinositol transfer proteins (PITPs) are key regulators of phosphoinositide signaling. Found in a diverse array of or

SUBMITTER: Lete MG 

PROVIDER: S-EPMC7986245 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature