Meta-analysis: Early Age at Natural Menopause and Risk for All-Cause and Cardiovascular Mortality.

ABSTRACT:

Aims

The aim of this meta-analysis was to comprehensively evaluate the association of early age at natural menopause with the risk for all-cause and cardiovascular mortality.

Methods

Literature retrieval was done on August 4, 2020. Article selection and data extraction were completed independently and in duplicate. Early age at natural menopause was grouped into premature menopause (<40 years), early menopause (40-44 years), and relatively early menopause (45-49 years). Effect-size estimates are summarized as hazard ratio (HR) or relative risk (RR) with 95% confidence interval (CI).

Results

Sixteen articles involving 321,233 women were meta-analyzed. Overall analyses revealed a statistically significant association of early age at natural menopause with all-cause mort

SUBMITTER: Huan L 

PROVIDER: S-EPMC7987413 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature