Intramyocardial Transplantation of Human iPS Cell-Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals.
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ABSTRACT:
SUBMITTER: Kawaguchi S
PROVIDER: S-EPMC7987543 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Intramyocardial Transplantation of Human iPS Cell-Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals.
Kawaguchi Shinji S Soma Yusuke Y Nakajima Kazuaki K Kanazawa Hideaki H Tohyama Shugo S Tabei Ryota R Hirano Akinori A Handa Noriko N Yamada Yoshitake Y Okuda Shigeo S Hishikawa Shuji S Teratani Takumi T Kunita Satoshi S Kishino Yoshikazu Y Okada Marina M Tanosaki Sho S Someya Shota S Morita Yuika Y Tani Hidenori H Kawai Yujiro Y Yamazaki Masataka M Ito Akira A Shibata Rei R Murohara Toyoaki T Tabata Yasuhiko Y Kobayashi Eiji E Shimizu Hideyuki H Fukuda Keiichi K Fujita Jun J
JACC. Basic to translational science 20210219 3
The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical sett ...[more]
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