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Catalpol Protects Against High Glucose-Induced Bone Loss by Regulating Osteoblast Function.

ABSTRACT: Objective: The overall objective of this study was to investigate the effects of catalpol on bone remodeling of diabetic osteoporosis by regulating osteoblast differentiation and migration. Method: Using a murine model of diabetic osteoporosis, to detect the protective effects of catalpol on bone loss, architectural deterioration of trabecular bone and bone metabolism biomarkers were tested. A model of MC3T3-E1 cells was established by treatment with high glucose; the regulatory role of catalpol in the differentiation and migration was tested by Western blot, ALP staining, and Alizarin Red staining. Results: Catalpol treatment markedly ameliorated trabecular bone deterioration by reducing degenerative changes of the trabecular structure by improving the bone formation marker levels of ALP, osteopontin, type I collagen, and osteocalcin, as well as the level of OPG/RANKL. Catalpol enhanced cell motility and scattering following gap formation of MC3T3-E1 cells. Conclusion: The results indicated that catalpol exhibits a protective effect against diabetic osteoporosis by regulating the differentiation and migration of osteoblast.

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7987667 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Catalpol Protects Against High Glucose-Induced Bone Loss by Regulating Osteoblast Function.

Zhao Lu L   Du Wei W   Zhao Dandan D   Ji Xueyan X   Huang Yanfei Y   Pang Yong Y   Guo Kaijin K   Yin Xiaoxing X  

Frontiers in pharmacology 20210310

<b>Objective:</b> The overall objective of this study was to investigate the effects of catalpol on bone remodeling of diabetic osteoporosis by regulating osteoblast differentiation and migration. <b>Method:</b> Using a murine model of diabetic osteoporosis, to detect the protective effects of catalpol on bone loss, architectural deterioration of trabecular bone and bone metabolism biomarkers were tested. A model of MC3T3-E1 cells was established by treatment with high glucose; the regulatory ro  ...[more]

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