Histologic grading of breast carcinoma: a multi-institution study of interobserver variation using virtual microscopy.

ABSTRACT: Breast carcinoma grading is an important prognostic feature recently incorporated into the AJCC Cancer Staging Manual. There is increased interest in applying virtual microscopy (VM) using digital whole slide imaging (WSI) more broadly. Little is known regarding concordance in grading using VM and how such variability might affect AJCC prognostic staging (PS). We evaluated interobserver variability amongst a multi-institutional group of breast pathologists using digital WSI and how discrepancies in grading would affect PS. A digitally scanned slide from 143 invasive carcinomas was independently reviewed by 6 pathologists and assigned grades based on established criteria for tubule formation (TF), nuclear pleomorphism (NP), and mitotic count (MC). Statistical analysis was performed. Interob

SUBMITTER: Ginter PS 

PROVIDER: S-EPMC7987728 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature