Diverse SARS-CoV-2 variants preceded the initial COVID-19 outbreak in Croatia.
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ABSTRACT: We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with different SARS-CoV-2 variants belonging to different clades (mostly G and GH). This result confirms that there was widespread virus transmission early in 2020. Interestingly, we identified a unique mutation resulting in a V13I substitution in Nsp5A, the main viral protease, in a patient who had not received antiviral therapy.
SUBMITTER: Rokic F
PROVIDER: S-EPMC7988246 | biostudies-literature |
REPOSITORIES: biostudies-literature
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