Abnormal semantic processing of threat words associated with excitement and hostility symptoms in schizophrenia.

ABSTRACT:

Background

Schizophrenia (SZ) is associated with devastating emotional, cognitive and language impairments. Understanding the deficits in each domain and their interactions is important for developing novel, targeted psychotherapies. This study tested whether negative-threat word processing is altered in individuals with SZ compared to healthy controls (HC), in relation to SZ symptom severity across domains.

Methods

Thirty-one SZ and seventeen HC subjects were scanned with functional magnetic resonance imaging while silently reading negative-threat and neutral words. Post-scan, subjects rated the valence of each word. The effects of group (SZ, HC), word type (negative, neutral), task period (early, late), and severity of clinical symptoms (positive, negative, excitement/host

SUBMITTER: Dar S 

PROVIDER: S-EPMC7988509 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature