An antibody targeting type III secretion system induces broad protection against Salmonella and Shigella infections.

ABSTRACT: Salmonella and Shigella bacteria are food- and waterborne pathogens that are responsible for enteric infections in humans and are still the major cause of morbidity and mortality in the emerging countries. The existence of multiple Salmonella and Shigella serotypes as well as the emergence of strains resistant to antibiotics requires the development of broadly protective therapies. Recently, the needle tip proteins of the type III secretion system of these bacteria were successfully utilized (SipD for Salmonella and IpaD for Shigella) as vaccine immunogens to provide good prophylactic cross-protection in murine models of infections. From these experiments, we have isolated a cross-protective monoclonal antibody directed against a conserved region of both proteins. Its conformational epitop

SUBMITTER: Sierocki R 

PROVIDER: S-EPMC7990167 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature