Dataset Information

SPON1 Is Associated with Amyloid-β and APOE ε4-Related Cognitive Decline in Cognitively Normal Adults.

ABSTRACT: .

Background

Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer's disease.

Objective

The aim of this study was to assess whether the association was present in cognitively normal older adults.

Methods

Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study.

Results

No independent effect of Spondin-1 rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between Apolipoprotein E (APOE) ɛ4 and rs11023139 in individuals with high amyloid-β burden. APOE ɛ4/rs11023139-A carriers declined significantly faster than APOE ɛ4/rs11023139-G_G carriers in measures of global cognition (p = 0.011) and verbal episodic memory (p = 0.020).

Conclusion

These results suggest that carriage of the Spondin-1 rs11023139-A allele significantly contributes to a worsening of cognitive performance in APOE ɛ4 cognitively normal older adults with a high neocortical amyloid-β burden.

SUBMITTER: Fernandez S

PROVIDER: S-EPMC7990462 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

<i>SPON1</i> Is Associated with Amyloid-β and <i>APOE</i> ε4-Related Cognitive Decline in Cognitively Normal Adults.

Fernandez Shane S Burnham Samantha C SC Milicic Lidija L Savage Greg G Maruff Paul P Peretti Madeline M Sohrabi Hamid R HR Lim Yen Ying YY Weinborn Michael M Ames David D Masters Colin L CL Martins Ralph N RN Rainey-Smith Stephanie S Rowe Christopher C CC Salvado Olivier O Groth David D Verdile Giuseppe G Villemagne Victor L VL Porter Tenielle T Laws Simon M SM

Journal of Alzheimer's disease reports 20210224 1

.<h4>Background</h4>Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer's disease.<h4>Objective</h4>The aim of this study was to assess whether the association was present in cognitively normal older adults.<h4>Methods</h4>Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lif ...[more]

PMID: 33782664

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