From biomechanics to pathology: predicting axonal injury from patterns of strain after traumatic brain injury.

ABSTRACT: The relationship between biomechanical forces and neuropathology is key to understanding traumatic brain injury. White matter tracts are damaged by high shear forces during impact, resulting in axonal injury, a key determinant of long-term clinical outcomes. However, the relationship between biomechanical forces and patterns of white matter injuries, associated with persistent diffusion MRI abnormalities, is poorly understood. This limits the ability to predict the severity of head injuries and the design of appropriate protection. Our previously developed human finite element model of head injury predicted the location of post-traumatic neurodegeneration. A similar rat model now allows us to experimentally test whether strain patterns calculated by the model predicts in vivo MRI and histo

SUBMITTER: Donat CK 

PROVIDER: S-EPMC7990483 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature