Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation.

ABSTRACT: The NR3C1 glucocorticoid receptor (GR) gene is a component of the stress response system, which can be regulated by epigenetic mechanisms. NR3C1 methylation has been associated with trauma and mental issues, including depression, post-traumatic stress, anxiety, and personality disorders. Previous studies have reported that stressful events are involved in NR3C1 gene methylation, suggesting that its regulation under environmental effects is complex. The present study aimed to analyze associations involving stressors such as socioeconomic status, health conditions, and lifestyle in relation to NR3C1 methylation in adults. This study included 386 individual users of the Brazilian Public Unified Health System (SUS), and evaluated socioeconomic and health conditions, body mass index, cortisol l

SUBMITTER: de Assis Pinheiro J 

PROVIDER: S-EPMC7990967 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature