Identification of Molecular Signatures in Mild Intrinsic Atopic Dermatitis by Bioinformatics Analysis.

ABSTRACT:

Background

Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals.

Objective

Since the limitation of dataset associated with human severe AD, this study aimed to screen potential novel biomarkers involved in mild AD.

Methods

Expression profile data (GSE75890) were obtained from the database of Gene Expression Omnibus. Using limma package, the differentially expressed genes (DEGs) between samples from AD and healthy control were selected. Furthermore, function analysis was conducted. Meanwhile, the protein-protein interaction (PPI) network and transcription factor (TF)-miRNA-target regulatory network were constructed. And quantitative real-time polymerase chain reaction (qRT-PCR) was used to val

SUBMITTER: Yin H 

PROVIDER: S-EPMC7992548 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature