Clinical Characteristics and Genetic Variations in Early-Onset Atopic Dermatitis Patients.

ABSTRACT:

Background

Hereditary factors contribute to atopic dermatitis (AD) development. We developed the reverse blot hybridization assay (REBA) kit to simultaneously detect variations in skin barrier- and immune response-related genes prevalent in Korean AD patients.

Objective

To identify genetic variations and clinical characteristics that could predict early AD development.

Methods

We compared AD-related genetic variations between early-onset AD subjects and non-AD controls, and clinical characteristics and genetic variations between early- and late-onset AD subjects. We compared 28 early-onset AD subjects and 57 non-AD controls from a birth cohort and 108 early- (age ≤3 years) and 90 late-onset AD subjects and 189 non-AD controls from a university hospital. Genetic variat

SUBMITTER: Kim BJ 

PROVIDER: S-EPMC7992730 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature