The community-curated Pristionchus pacificus genome facilitates automated gene annotation improvement in related nematodes.

ABSTRACT:

Background

The nematode Pristionchus pacificus is an established model organism for comparative studies with Caenorhabditis elegans. Over the past years, it developed into an independent animal model organism for elucidating the genetic basis of phenotypic plasticity. Community-based curations were employed recently to improve the quality of gene annotations of P. pacificus and to more easily facilitate reverse genetic studies using candidate genes from C. elegans.

Results

Here, I demonstrate that the reannotation of phylogenomic data from nine related nematode species using the community-curated P. pacificus gene set as homology data substantially improves the quality of gene annotations. Benchmarking of universal single copy orthologs (BUSCO) estimates a median completenes

SUBMITTER: Rodelsperger C 

PROVIDER: S-EPMC7992802 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature