Unknown

Dataset Information

0

Synthesis of functionalized tetrahydropyrans via cascade cycloaddition involving silyloxyallyl cation intermediates.

ABSTRACT: An expedient synthesis of highly substituted tetrahydrobenzofuran via an unsymmetrical silyloxyallyl cation is reported. Conveniently generated under catalytic Brønsted acid conditions, nucleophilic capture of this reactive intermediate by silylenolate, followed by Paal-Knorr cascade cyclization in the presence of tosic acid monohydrate effectively constructed the tetrahydrobenzofuran core in a single synthetic step.

SUBMITTER: Badmus FO 

PROVIDER: S-EPMC7992855 | biostudies-literature |

REPOSITORIES: biostudies-literature

Json Xml

Similar Datasets

Unknown Asymmetric Synthesis of Functionalized Dihydro- and Tetrahydropyrans via an Organocatalytic Domino Michael-Hemiacetalization Reaction.
| S-EPMC4181541 | biostudies-literature
Unknown General method for functionalized polyaryl synthesis via aryne intermediates.
| S-EPMC4227807 | biostudies-other
Unknown Asymmetric synthesis of highly functionalized tetrahydropyrans via a one-pot organocatalytic Michael/Henry/ketalization sequence.
| S-EPMC4700516 | biostudies-literature
Unknown Biomimetic Total Synthesis of (±)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade.
| S-EPMC5718057 | biostudies-literature
Unknown Total synthesis of (+/-)-strychnine via a [4 + 2]-cycloaddition/rearrangement cascade.
| S-EPMC2587098 | biostudies-literature
Unknown Synthesis of functionalized organotrifluoroborates via the 1,3-dipolar cycloaddition of azides.
| S-EPMC2515368 | biostudies-literature
Unknown Synthesis of (+/-)-3H-epivincamine via a Rh(II)-triggered cyclization/cycloaddition cascade.
| S-EPMC2587099 | biostudies-literature
Unknown Synthesis of functionalized cyclohexenone core of welwitindolinones via rhodium-catalyzed [5 + 1] cycloaddition.
| S-EPMC3480994 | biostudies-literature
Unknown Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction
| S-EPMC6264231 | biostudies-literature
Unknown A facile synthesis of functionalized dispirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction.
| S-EPMC6270352 | biostudies-literature