Ontology highlight
ABSTRACT:
SUBMITTER: Harel M
PROVIDER: S-EPMC7993352 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Harel Michal M Ortenberg Rona R Varanasi Siva Karthik SK Mangalhara Kailash Chandra KC Mardamshina Mariya M Markovits Ettai E Baruch Erez N EN Tripple Victoria V Arama-Chayoth May M Greenberg Eyal E Shenoy Anjana A Ayasun Ruveyda R Knafo Naama N Xu Shihao S Anafi Liat L Yanovich-Arad Gali G Barnabas Georgina D GD Ashkenazi Shira S Besser Michal J MJ Schachter Jacob J Bosenberg Marcus M Shadel Gerald S GS Barshack Iris I Kaech Susan M SM Markel Gal G Geiger Tamar T
Cell 20190905 1
Immunotherapy has revolutionized cancer treatment, yet most patients do not respond. Here, we investigated mechanisms of response by profiling the proteome of clinical samples from advanced stage melanoma patients undergoing either tumor infiltrating lymphocyte (TIL)-based or anti- programmed death 1 (PD1) immunotherapy. Using high-resolution mass spectrometry, we quantified over 10,300 proteins in total and ∼4,500 proteins across most samples in each dataset. Statistical analyses revealed highe ...[more]